NLRP3 Inflammasome Inhibitor I

SKU: orb1225986

Description

It is a NLRP3 Inflammasome Inhibitor I.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 16673-34-0
• MW: 368.83
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇ClN₂O₄S
• SMILES: O=C(NCCC1=CC=C(S(=O)(N)=O)C=C1)C2=CC(Cl)=CC=C2OC
• Target: NOD
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  NLRP3-IN-2 is well tolerated with no effects on the glucose levels In vivo. NLRP3-IN-2 (100 mg/kg) treatment in a model of AMI due to ischemia+reperfusion significantly inhibits the activity of inflammasome (caspase-1) in the heart by 90% (P<0.01) and reduced infarct size, measured at pathology (by >40%, P<0.01) and with troponin I levels (by >70%, P<0.01). Animal model: Experimental acute myocardial infarction (AMI) model in mice. Dosage: 100 mg/kg. Administration: Intraperitoneal administration 30 minutes prior to surgery, then every 6 hours for 3 additional doses. Result: Led to a significant >90% reduction in caspase-1 activity (reflective of the formation of an active inflammasome) in the heart tissue measured 24 hours after ischemia. Led to a significant reduction in the infarct size measured with TTC (>40% reduction) or troponin I levels (>70% reduction) when compared with vehicle alone.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glibenclamide impurity A | Glibenclamide A | Glyburide Related Compound A | NLRP3 Inflammasome Inhibitor I

Quick Database Links

Gene Symbol

NOD