NEK7-IN-1

SKU: orb2814290

Description

NEK7-IN-1 (Compound I-15) is a potent and selective small molecule inhibitor of NEK7, demonstrating IC50 values below 100 nM for the kinase and under 50 nM for IL-1β release inhibition. This tool compound is widely applied in biochemical and cellular assays to investigate NEK7's role in NLRP3 inflammasome activation and inflammatory disease models, both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2738569-12-3
• MW: 614.64
• Formula: C₃₀H₃₄F₄N₈O₂
• SMILES: O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)NC=3C=CC(=CC3F)C4=CN(C=5N=CN=C(N)C45)CC(O)(C)C
• Target: MAPK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

165404334