CAII-IN-11

SKU: orb3175023

Description

CAII-IN-11 (Compound A1) is a dual-targeted compound that includes an hCA II inhibitor segment (IC50= 2 nM) and a NO donor component. It also shows inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM, respectively. CAII-IN-11 significantly elevates cGMP levels in human trabecular meshwork cells. Furthermore, it reduces apoptosis of retinal ganglion cells by decreasing oxidative stress (ROS levels), inhibiting astrocytes, and NLRP3 inflammasome activation. In a rabbit model, CAII-IN-11 demonstrates intraocular pressure-lowering activity, making it a potential candidate for glaucoma research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• Target: Carbonic Anhydrase,Apoptosis,ROS,NOD-like Receptor (NLR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Carbonic Anhydrase,Apoptosis,ROS,NOD-like Receptor (NLR)