Nivolumab

• Catalog Number: orb1290228
• Category: Antibodies
• Description: Nivolumab biosimilar antibody
• Species/Host: Mouse
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human
• CAS Number: 946414-94-4
• Isotype: IgG4-kappa
• Antibody Type: Biosimilar Antibody
• Purity: > 95%
• Conjugation: Unconjugated
• Target: PDCD1/PD1/CD279
• Source: CHO cells
• Biological Activity: Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: PBS buffer pH 7.5
• Alternative names: BMS-936558, MDX-1106, ONO-4538
• Note: For research use only
• Expiration Date: 12 months from date of receipt.