Neurotensin

SKU: orb1296663

Description

Neurotensin

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 39379-15-2
• MW: 1672.92
• Purity: 100.00%
• Formula: C₇₈H₁₂₁N₂₁O₂₀
• SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CC(C)C)C(O)=O
• Target: Neurotensin Receptor
• Solubility: DMSO:10 mM;H2O:36.43 mg/mL (21.78 mM)

Bioactivity

• In Vitro:
  Neurotensin induce the expression of inflammatory markers (MIP-2, MCP-1, IL-1β, TNFα) in murine microglial cells and promotes IL-8 secretion in colon epithelial cells harborin the NTR, a high-affinity receptor belonging to the GPCR family, prevalent in many pancreatic and colorectal cancers. This suggests Neurotensin's potential endocrine role in tumor growth. Acting through NTR1, it activates several signal transduction pathways, including intracellular calcium levels, MAPKs (ERK, JNK), and PKC isoforms. In HCT116 cancer cells, Neurotensin dramatically enhances migration approximately threefold, an effect inhibited by Curcumin pretreatment. Additionally, Neurotensin's activation o the MEK/ERK pathway and subsequent upregulation of AP-1 transcription factors underscore its contribution to cell proliferation.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, NeurotensinReceptor, Neurotensin Receptor, Neurotensin

Compound Identifiers

PubChem CID

25077406