Nebivolol hydrochloride

SKU: orb1310888

Description

Nebivolol hydrochloride is a cardioselective beta-1 adrenergic receptor antagonist that also acts as a vasodilator by modulating the endothelial nitric oxide pathway. It is utilized in research models of hypertension and chronic heart failure, with applications in both in vivo cardiovascular studies and in vitro receptor pharmacology assays.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 152520-56-4
• MW: 441.90
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₂₅F₂NO₄·HCl
• SMILES: Cl.OC(CNCC(O)C1CCc2cc(F)ccc2O1)C1CCc2cc(F)ccc2O1
• Target: Adrenergic Receptor,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.53 mM);Ethanol:4.42 mg/mL (10 mM);DMSO:60 mg/mL (135.78 mM)

Bioactivity

• Target IC50:
  β1-adrenoceptor:0.8 nM
• In Vivo:
  Nebivolol reduced the proliferation of coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent manner.Nebivolol acted with high affinity and selectivity at the beta 1-adrenergic receptor site in the preparation of rabbit lung membranes.Nebivolol treatment of haCSMCs for 7 days significantly inhibited cell proliferation (IC50 ~ 10 μM). Nebivolol treated haCSMCs for 7 days, significantly inhibited cell proliferation (IC50: 6.1 μM). nebivolol treated haCSMCs for 48 hours, the apoptosis rate was 23%, and reduced the number of S-phase cells.
• In Vitro:
  Nebivolol treatment of rats with myocardial infarction lowered mean blood pressure by a small amount. Nebivolol reduced myocardial apoptosis in rats with myocardial infarction when administered intravenously for 10 minutes followed by oral administration.
• Cell Research:
  Cells are exposed to different concentrations of Nebivolol (10-7~10-5 M) for 1, 2, 4, 7 and 14 days. Cell proliferation is analyzed by bromodeoxyuridine (BrdU) incorporation, and cell apoptosis is detected by PI or annexin V staining.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nebivolol, Nebivolol HCl, Nebivolol hydrochloride, Nebivolol Hydrochloride, oral, inhibit, ischemic heart disease, Inhibitor, hypertension, Apoptosis, Adrenergic Receptor, adrenergic blocking, AdrenergicReceptor, congestive heart failure, coronary artery disease, Beta Receptor, β1-adrenoceptor, vasodilator, R 065824, R 065824 hydrochloride, R 065824 Hydrochloride, R65824, R-65824, R 65824, R065824, R-065824, R065824 Hydrochloride, R-065824 Hydrochloride

Compound Identifiers

PubChem CID

9933004