Nebivolol hydrochloride

SKU: orb1226151

Description

Nebivolol hydrochloride selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM.(In Vitro):Nebivolol hydrochloride improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties.Nebivolol hydrochloride (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM.Nebivolol hydrochloride (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis.Nebivolol hydrochloride (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs

Key Properties

• CAS Number: 152520-56-4
• MW: 441.9
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₅F₂NO₄·HCl
• SMILES: O[C@@H]([C@H]1CCC2=C(O1)C=CC(F)=C2)CNC[C@H](O)[C@@H]3CCC4=C(O3)C=CC(F)=C4.[H]Cl
• Target: Adrenergic Receptor
• Solubility: DMSO: 88 mg/mL (199.14 mM)

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: haCSMCs (human coronary smooth muscle cells) and haECs (endothelial cells). Concentration: 0.1 μM-10 μM Incubation time: 1, 2, 4, 7 or 14 days. Result: Reduced proliferation in HaECs and HaCSMCs in a concentration- and time-dependent. Apoptosis Analysis Cell line: haCSMCs and haECs. Concentration: 0.1 μM-10 μM Incubation time: 24 h. Result: Induced a moderate apoptosis in concentration-dependent and showed a decrease of haCSMCs in the S-phase by 66%.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nebivolol HCl | Nebivolol Hydrochloride | Silostar | Bystolic, R-67145 | R 67145 | R67145

Quick Database Links

Gene Symbol

Adrenergic Receptor