Napabucasin

SKU: orb1304413

Description

Napabucasin

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 83280-65-3
• MW: 240.21
• Purity: 99.35%
• Formula: C₁₄H₈O₄
• SMILES: CC(=O)c1cc2c(o1)C(=O)c1ccccc1C2=O
• Target: STAT
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);acetonitrile:0.8 mg/mL (3.33 mM);DMSO:6.88 mg/mL (28.64 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis.
• In Vitro:
  Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on Inhibition on normal stem cells.
• Cell Research:
  For cancer stem cells, spheres are dissociated and plated under cancer stem cell culture conditions on coated 96-well plates. After 72 h of culture, wells are dosed wit the indicated compounds. Seventy-two hours or 24 h after dosing, CellTiter-Glo 2.0 is added to Each well, an the luminescence is measured as described b the manufacturer. IC50 Values are calculated by fitting a four parameter dose–response curve to normalized data using GraphPad Prism software. For bulk cells, cells are plated at 5,000 cells per well on 96-well plates. Twenty-four hours after plating, cells are treated wit the indicated compounds. Viability is determined at 72 h as described above.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

BBI 608, BBI608, BBI-608, Napabucasin, inhibit, Inhibitor, STAT3, STAT

Compound Identifiers

PubChem CID

10331844