XD2-149

SKU: orb1910989

Description

XD2-149 is a napabucasin PROTAC as an effective degrader of the E3 ligase ZFP91 with IC50 of 1 μM and 0.8 μM in pancreatic cancer cell lines, MIA PaCa-2 and BxPC-3, respectively. XD2-149 also reduces the expression of STAT3, pSTAT3, and NQO1 proteins.

Key Properties

• MW: 693.757
• Formula: C₃₈H₃₉N₅O₈
• SMILES: O=C(CC1)NC(C1N(C2=O)C(C3=C2C(NCCCCCC(CC4)CCN4CCNC(C(O5)=CC6=C5C(C7=C(C6=O)C=CC=C7)=O)=O)=CC=C3)=O)=O

Storage & Handling

• Disclaimer: For research use only