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N-Nornuciferine

SKU: orb1678997

Description

N-Nornuciferine

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number4846-19-9
MW281.35
Purity99.63%
FormulaC18H19NO2
SMILESO(C)C1=C2C=3[C@@](CC=4C2=CC=CC4)(NCCC3C=C1OC)[H]
TargetCytochromes P450
SolubilityDMSO:80 mg/mL (284.34 mM)

Bioactivity

Target IC50
CYP2D6:3.76 μM|CYP2D6:2.34 μM (Ki)
In Vitro
N-Nornuciferine exhibits potent inhibitory effects on CYP2D6 enzyme activity, while demonstrating only weak or no inhibitory effects on the other four cytochrome P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). Furthermore, N-Nornuciferine competitively inhibits the CYP2D6-catalyzed O-demethylation reaction of dextromethorphan, with a Ki value of 2.34 μM .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NNornuciferine, N-Nornuciferine, N Nornuciferine, CYP2D6

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Key Properties

No computed properties available.

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N-Nornuciferine (orb1678997)

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20 mg
$ 510.00
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