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N-Nornuciferine

SKU: orb1678997

Description

N-Nornuciferine

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number4846-19-9
MW281.35
FormulaC18H19NO2
SMILESCOc1cc2CCN[C@@H]3Cc4ccccc4-c(c1OC)c23
TargetCytochromes P450
SolubilityDMSO:80 mg/mL (284.34 mM)

Bioactivity

Target IC50
CYP2D6:3.76 μM|CYP2D6:2.34 μM (Ki)
In Vitro
N-Nornuciferine exhibits potent inhibitory effects on CYP2D6 enzyme activity, while demonstrating only weak or no inhibitory effects on the other four cytochrome P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). Furthermore, N-Nornuciferine competitively inhibits the CYP2D6-catalyzed O-demethylation reaction of dextromethorphan, with a Ki value of 2.34 μM .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NNornuciferine, N-Nornuciferine, N Nornuciferine, CYP2D6

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Key Properties

No computed properties available.

Protocol Information

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20 mg
$ 340.00
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