N-Nornuciferine hydrochloride(4846-19-9 free base)

SKU: orb1296070

Description

N-Nornuciferine hydrochloride, derived from the aporphine alkaloid found in lotus leaf, is a potent and selective inhibitor of the cytochrome P450 enzyme CYP2D6 (IC₅₀ 3.76 µM, Kᵢ 2.34 µM). This small molecule is a valuable research tool for in vitro drug metabolism studies and investigating CYP2D6-mediated pharmacokinetic interactions.

Research Area

Metabolism Research

Key Properties

• MW: 317.81
• Purity: 99.63% (May vary between batches)
• Formula: C₁₈H₂₀ClNO₂
• SMILES: Cl.[H][C@]12Cc3ccccc3-c3c(OC)c(OC)cc(CCN1)c23
• Target: Cytochromes P450
• Solubility: DMSO:25 mg/mL (78.66 mM)

Bioactivity

• In Vitro:
  N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan O-demethylation (Ki: 2.34 μM).

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-Nornuciferine hydrochloride, N-Nornuciferine Hydrochloride, NNornuciferine hydrochloride(4846199 free base), N Nornuciferine hydrochloride(4846 19 9 free base), CYP2D6

Compound Identifiers

PubChem CID

155977511