MW-150

SKU: orb1301743

Description

MW-150 (MW01-18-150SRM) is a potent, selective, and brain-penetrant p38α MAPK inhibitor with a Ki of 101 nM. Its oral activity facilitates research into neuroinflammation, making it a valuable tool for in vitro and in vivo studies of CNS disorders.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1628502-91-9
• MW: 381.47
• Purity: 99.32% (May vary between batches)
• Formula: C₂₄H₂₃N₅
• SMILES: CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1
• Target: p38 MAPK,Autophagy
• Solubility: DMSO:6.25 mg/mL (16.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.62 mM)

Bioactivity

• Target IC50:
  p38α:101 nM (Ki)
• In Vitro:
  MW-150 treatment blocked in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values for these MW150 cellular activities are 332 nM (MK2) and 936 nM (IL-1β), values which are consistent with the in vitro Ki of 101 nM for p38αMAPK.
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• Animal Research:
  MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p38 MAPK, p38MAPK, p38α, inhibit, MW 150, MW01-18-150SRM, MW150, MW-150, Inhibitor, Autophagy

Compound Identifiers

PubChem CID

86270361