MW-150

SKU: orb1226023

Description

MW-150 (MW01-18-150 SRM) is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM; effectively suppresses hippocampal-dependent associative and spatial memory deficits in synaptic dysfunction mouse models; also can selectively modulate neuroinflammatory responses associated with pathology progression.

Key Properties

• CAS Number: 1628502-91-9
• MW: 381.483
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₃N₅
• SMILES: CN1CCN(CC1)C2=NN=C(C(=C2)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4
• Target: p38 MAPK
• Solubility: In Vitro: DMSO : 40 mg/mL (104.86 mM)

Bioactivity

• In Vivo:
  MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests. MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice. Animal model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta). Dosage: 2.5 mg/kg. Administration: Oral daily; 3-4 months (until cognitive impairment is present). Result: Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
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• In Vitro:
  MW-150 inhibits in a concentration-dependent manner the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia. MW-150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MW01-18-150SRM | MW 150 | MW150

Quick Database Links

Gene Symbol

p38 MAPK