mTOR inhibitor 13

SKU: orb1685302

Description

Urea, N-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]-N'-3-pyridinyl-

Research Area

Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1144075-44-4
• MW: 458.54
• Purity: 99.24% (May vary between batches)
• Formula: C₂₄H₂₂N₆O₂S
• SMILES: N(C(NC=1C=CC=NC1)=O)C2=CC=C(C3=NC(=C4C(=N3)C=CS4)N5CC6OC(C5)CC6)C=C2
• Target: PI3K,mTOR
• Solubility: DMSO:45 mg/mL (98.14 mM)

Bioactivity

• Target IC50:
  mTOR:0.29nM|PI3Kα:119nM
• In Vitro:
  mTOR inhibitor 13 inhibits the growth of LNCaP cell with IC50 of 27nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, mTOR inhibitor 13, PI3Kα, Urea, N ​[4 ​[4 ​(8 ​oxa ​3 ​azabicyclo[3.2.1]​oct ​3 ​yl)​thieno[3,​2 ​d]​pyrimidin ​2 ​yl]​phenyl]​ ​N' ​3 ​pyridinyl , Urea, N​[4​[4​(8​oxa​3​azabicyclo[3.2.1]​oct​3​yl)​thieno[3,​2​d]​pyrimidin​2​yl]​phenyl]​​N'​3​pyridinyl

Compound Identifiers

PubChem CID

46227572