Vicenin 2

SKU: orb1303664

Description

Vicenin 2 is a bioactive flavonoid from Desmodium styracifolium with multiple inhibitory activities, including against ACE, α-glucosidase, and PTP1B. It demonstrates hepatoprotective, anticancer, and anti-inflammatory properties in vitro and shows synergistic effects in prostate cancer models. This compound is a promising multi-target lead for researching diabetes complications and oxidative stress.

Research Area

Metabolism Research

Key Properties

• CAS Number: 23666-13-9
• MW: 594.52
• Purity: 99.99% (May vary between batches)
• Formula: C₂₇H₃₀O₁₅
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)c([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2oc(cc(=O)c2c1O)-c1ccc(O)cc1
• Target: RAAS,Angiotensin-converting Enzyme (ACE)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.36 mM);DMSO:150 mg/mL (252.3 mM)

Bioactivity

• Target IC50:
  ACE:43.83 μM
• In Vitro:
  Lychnophora salicifolia, commonly known as 'arnicão', is used as an anti-inflammatory agent and as a flavoring agent in the Brazilian traditional spirit 'cachaça'.METHODS AND RESULTS: In this work, the permeation process of Vicenin -2 (1) and lychnopholic acid (2) (major secondary metabolites from the hydroalcoholic extract) was investigated using Caco-2 cells. For this investigation, a new HPLC-DAD method was developed and validated for the quantification step. It was observed that 2 crosses the Caco-2 cell monolayer by passive diffusion. On the other hand, 1 was not transported, suggesting no absorption and no efflux of this compound in Caco-2 cells.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

c-Myc, ACE, Akt, Angiotensin-converting Enzyme (ACE), p53, inhibit, mTOR, EGFR, Inhibitor, Vicenin 2, Vicenin -2, Vicenin2, Vicenin-2

Compound Identifiers

PubChem CID

442664