CC-115

SKU: orb1304086

Description

CC-115 is a potent dual inhibitor of mTOR and DNA-PK with IC50 values of 21 nM and 13 nM, respectively. It is a valuable research tool for studying DNA damage response and signaling pathways in oncology research, applicable in both cellular and animal models.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 1228013-15-7
• MW: 336.35
• Purity: 99.22% (May vary between batches)
• Formula: C₁₆H₁₆N₈O
• SMILES: CCN1C(=O)CNc2ncc(nc12)-c1ccc(nc1C)-c1ncn[nH]1
• Target: DNA-PK,PI3K,mTOR
• Solubility: DMSO:62 mg/mL (184.33 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.95 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  mTOR:21nM|PI3Kα:852 nM|DNA-PK:13 nM
• In Vivo:
  CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for Clinicalal development.
• In Vitro:
  The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM).
• Cell Research:
  Freshly isolated CLL cells are treated with different concentrations of CC-115 for 30 minutes. Subsequently, the cells are exposed to 5-Gy γ-radiation or treated with 10 µg/mL bleomycin (EMD Millipore, Billerica, MA) and incubated for 30 minutes, and cell lysates are made. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, mTOR, Inhibitor, Mammalian target of Rapamycin, DNA-dependent protein kinase, DNAPK, DNA-PK, CC115, CC-115, CC 115, PI3Kα

Compound Identifiers

PubChem CID

58298318