ML-SI3

SKU: orb1298263

Description

ML-SI3 is a selective small-molecule inhibitor of TRPML1, TRPML2, and TRPML3 calcium channels. It serves as a valuable research tool for investigating the role of these channels in lysosomal function, with applications in studies of neurodegenerative and cardiovascular disease models both in vitro and in vivo.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 891016-02-7
• MW: 429.58
• Purity: 99.94%
• Formula: C₂₃H₃₁N₃O₃S
• SMILES: COc1ccccc1N1CCN(CC1)C1CCCCC1NS(=O)(=O)c1ccccc1
• Target: TRP/TRPV Channel,Glucagon Receptor,Parasite
• Solubility: DMSO:65 mg/mL (151.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.33 mM)

Bioactivity

• Target IC50:
  TRPML3:12.5 μM|TRPML2:1.7 μM|TRPML1:4.7 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML-SI3, GlucagonReceptor, Glucagon Receptor, GLP-1, CCG143140, CCG-143140, CCG 143140, TRPVChannel, TRPChannel, TRPV Channel, TRP Channel

Compound Identifiers

PubChem CID

23604942