CCG-143140

SKU: orb1217524

Description

CCG-143140 is a GLP-1 receptor inverse agonists.

Key Properties

• CAS Number: 891016-02-7
• MW: 429.58
• Purity: >98% (HPLC)
• Formula: C₂₃H₃₁N₃O₃S
• SMILES: O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O
• Target: Glucagon Receptor
• Solubility: In Vitro: DMSO : 50 mg/mL (116.39 mM)

Bioactivity

• In Vivo:
  ML-SI3 (1.5 mg/kg, i.p. , four times) attenuates I/R injury in mouse cardiomyocytes. Animal model: myocardial ischemia/reperfusion (I/R) injury mice. Dosage: 1.5 mg/kg. Administration: Intraperitoneal injection (i.p.), four times before and during In vivo I/R (ischemia 30 min and reperfusion 1 day). Result: Restored the blocked autophagic flux in the cardiomyocytes subjected to I/R.
• In Vitro:
  ML-SI3 (10 μM) inhibits ML-SA1-evoked Ca2+ signals in HeLa cells. ML-SI3 (25-75 μM, 24h) disrupts tegumental integrity of adult schistosomes. ML-SI3 (10 μM) blocks Rapamycin (HY-10219)-evoked ITRPML1 in mimic of lysosomal lumen. ML-SI3 (3 μM, 6 h) abolishes the increase in both LC3II and p62 levels induced by hypoxia/reoxygenation (H/R) (4 h H/2 h R) in neonatal rat ventricular myocytes (NRVM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML-SI3

Quick Database Links

Gene Symbol

Glucagon Receptor