Mebendazole

SKU: orb1309581

Description

Mebendazole is a broad-spectrum anthelmintic compound that acts by inhibiting tubulin polymerization. It is widely used in research for studying helminth infections and has demonstrated utility in both in vivo parasite clearance models and in vitro cytotoxicity assays against various cell lines.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 31431-39-7
• MW: 295.29
• Purity: 99.51% (May vary between batches)
• Formula: C₁₆H₁₃N₃O₃
• SMILES: O=C(OC)NC1=NC=2C=CC(=CC2N1)C(=O)C=3C=CC=CC3
• Target: Parasite,Apoptosis,Microtubule Associated
• Solubility: DMSO:10 mg/mL (33.87 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice.
• In Vitro:
  mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells.
• Cell Research:
  When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.(Only for Reference)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Telmin, Tubulin α-1A chain, Tubulin β-4B chain, Vermox, Apoptosis, Mebendazole, Mebenvet, Inhibitor, inhibit, MicrotubuleAssociated, Microtubule Associated, Parasite, Pantelmin

Compound Identifiers

PubChem CID

4030