Mebendazole

SKU: orb1309581

Description

Mebendazole

Research Area

Cell Biology, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 31431-39-7
• MW: 295.29
• Purity: 99.80%
• Formula: C₁₆H₁₃N₃O₃
• SMILES: COC(=O)NC1=NC2=C(N1)C=CC(=C2)C(=O)C1=CC=CC=C1
• Target: Microtubule Associated,Parasite,Apoptosis
• Solubility: DMSO:10 mg/mL (33.87 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  When administered p.o. To nu/nu mice, MZ strongly inhibit the growth of human tumor xenografts and significantly reduce the number and size of tumors in an Experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice.
• In Vitro:
  mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells a the G2-M phase befor the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cell.
• Cell Research:
  When grown to 40–50% confluence the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by countin the viable cells using a hemacytometer.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Telmin, Tubulin α-1A chain, Tubulin β-4B chain, Vermox, Apoptosis, Mebendazole, Mebenvet, Inhibitor, inhibit, MicrotubuleAssociated, Microtubule Associated, Parasite, Pantelmin

Compound Identifiers

PubChem CID

4030