Oxantel Pamoate

SKU: orb1224240

Description

Oxantel pamoate is used as Antinematodal Agent.(In Vivo):The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus.

Key Properties

• CAS Number: 68813-55-8
• MW: 604.65
• Purity: >98% (HPLC)
• Formula: C₃₆H₃₂N₂O₇
• SMILES: CN1CCCN=C1C=CC1=CC(O)=CC=C1.CN1CCCN=C1C=CC1=CC(O)=CC=C1.OC(=O)C1=C(CC2=C(C(O)=O)C(O)=CC3=CC=CC=C23)C2=CC=CC=C2C=C1O
• Target: Antiparasitic
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI) = 2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI = 1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI = 0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Antiparasitic