Mebendazole

SKU: orb1225332

Description

A highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.Parasite Infection Approved.

Key Properties

• CAS Number: 31431-39-7
• MW: 295.2927
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₃N₃O₃
• SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3
• Target: Parasite
• Solubility: DMSO: ≥ 23 mg/mL

Bioactivity

• In Vivo:
  Animal model: C57BL/6 mice (5-6 weeks old) implanted with GL261 glioma cells and 060919 human glioblastoma multiforme (GBM). Dosage: 50 mg/kg; delivered with 50% (v/v) sesame oil and PBS. Administration: Oral gavage; beginning 5 days after tumor implantation at a daily dose of 50 mg/kg for the first 20 days of treatment then changed to 50 mg/kg for 5 days, with 2 days off, each week. Result: Increased the mean survival to 49 days compared with the 30 days of control in syngeneic GL261 mouse model. Increased the mean survival to 65 days compared with the 48 days of control in 060919 human glioblastoma multiforme (GBM) xenograft mouse model.
• In Vitro:
  Immunofluorescence Cell line: Glioblastoma multiforme (GBM) 060919 cells. Concentration: 1 μM. Incubation time: 24 hours. Result: Disrupted microtubule structure. Immunofluorescence Cell line: DAOY and hTERT-RPE1 cells. Concentration: 0, 0.1, 0.5, 0.75, and 1 μM Incubation time: 12 hours. Result: Decreased GLI1 protein level and increased cleavage of caspase-3 protein level.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 184849 | R 17635

Quick Database Links

Gene Symbol

Parasite