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Mcl-1 inhibitor 3

SKU: orb1709173

Description

This macrocyclic compound is a highly potent and orally bioavailable Mcl-1 inhibitor, demonstrating sub-nanomolar binding affinity (Ki=0.061 nM) and cellular activity (IC50=19 nM in OPM-2 cells). It exhibits favorable pharmacokinetics and has shown excellent in vivo efficacy in research models without reported toxicity, making it a valuable tool for studying apoptosis and cancer biology.

Research Area

Cell Biology, Pharmacology & Drug Discovery; Cell Biology

Images & Validation

Key Properties

CAS Number2376774-73-9
MW820.39
FormulaC40H52ClF2N5O7S
SMILES[H][C@@]12CC[C@@]1([H])[C@@H](OCCN1CC(F)(F)C1)\C=C/CCN(C)C(=O)C[C@](O)(C(=O)NS(=O)(=O)N(C)C)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1 |c:18|
TargetBcl-2 Family

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information