AZ-PFKFB3-67

SKU: orb1701114

Description

AZ-PFKFB3-67 is a selective PFKFB3 inhibitor (IC50=11 nM) that suppresses angiogenesis by reducing lactate and ATP in endothelial cells during tube formation. It also lowers MCL-1 levels and demonstrates neuroprotective properties, making it a useful tool for oncology and neurobiology research.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1704741-11-6
• MW: 455.51
• Purity: 99.79% (May vary between batches)
• Formula: C₂₆H₂₅N₅O₃
• SMILES: C(#N)C=1C=2C(N(CC=3C(C)=NOC3C)C1)=CC=C(OC4=CC=C(NC(=O)[C@@H]5CCCN5)C=C4)C2
• Target: Bcl-2 Family,Glucokinase,Phosphatase,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.39 mM);DMSO:80 mg/mL (175.63 mM)

Bioactivity

• Target IC50:
  Intracellular F-2,6-BP production:0.281 μM|PFKFB1:1130 nM|PFKFB3:11 nM|PFKFB2:159 nM
• In Vitro:
  AZ-PFKFB3-67 is a highly selective PFKFB3 inhibitor with strong target inhibitory activity, exhibiting IC₅₀ values of 1.13 μM for PFKFB1, 0.159 μM for PFKFB2, and 0.011 μM for PFKFB3. In cellular assays, AZ-PFKFB3-67 inhibits fructose-2,6-bisphosphate (F-2,6-BP) production with an IC₅₀ of 0.281 μM, while having minimal effect on cellular lactate levels (IC₅₀ > 30 μM), indicating a pronounced inhibitory effect on early glycolytic regulation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZPFKFB367, AZ-PFKFB367, AZ-PFKFB-3-67, AZ-PFKFB3-67, AZPFKFB3-67, AZ PFKFB3 67

Compound Identifiers

PubChem CID

91668554