MAVS (N) Antibody, Rabbit Polyclonal

SKU: orb131803

Description

Rabbit polyclonal to MAVS. Mitochondrial antiviral-signaling protein (MAVS) is required for innate immune defense against viruses. Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. MAVS may activate the same pathways following detection of extracellular dsRNA by TLR3 and may also protect cells from apoptosis.

Research Area

Infectious Disease & Virology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human, Mouse
• Application Notes:
  WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human MAVS.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human MAVS
• Molecular Weight: 57
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti Mitochondrial antiviral-signaling protein antibody, anti MAVS antibody, anti CARD adapter inducing interferon beta antibody, anti Cardif antibody, anti Interferon beta promoter stimulator protein 1 antibody, anti IPS-1 antibody, anti Putative NF-kappa-B-activating protein 031N antibody, anti Virus-induced-signaling adapter antibody, anti VISA antibody, anti IPS1 antibody, anti KIAA1271 antibody, anti VISA antibody

Quick Database Links

UniProt

Q7Z434