L-Glutamic acid

SKU: orb1304751

Description

L-Glutamic acid is a major excitatory neurotransmitter that acts as an agonist at ionotropic (AMPA, NMDA, KA) and metabotropic (mGluR) glutamate receptors. It is widely used in neuroscience research to study receptor function, dopaminergic interactions, and models of neurological diseases in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 56-86-0
• MW: 147.13
• Purity: 99.14%
• Formula: C₅H₉NO₄
• SMILES: [C@H](CCC(O)=O)(C(O)=O)N
• Target: Ferroptosis,Apoptosis,Endogenous Metabolite,iGluR
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:8.27 mg/mL (56.21 mM)

Bioactivity

• Target IC50:
  CHO cells:1.2 μM|HEK293 cells:0.06 μM|BHK-21 cells:1.8 μM (EC50)|Oocyte:0.45 μM
• In Vitro:
  METHODS: SH-SY5Y cells were treated with L-Glutamic acid (10, 20, 30 mM) for 3 hours, and cell viability was detected using the MTT assay. RESULTS: L-Glutamic acid reduced the viability of SH-SY5Y cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, (S)-Glutamic acid, (+)-L-Glutamic acid, L Glutamic acid, glutamic acid, glutacid, EndogenousMetabolite, Endogenous Metabolite, Ferroptosis, LGlutamic acid, L-Glutamic acid, iGluR

Compound Identifiers

PubChem CID

33032