L-Arginine hydrochloride

SKU: orb1310400

Description

L-Arginine hydrochloride serves as the substrate for endothelial nitric oxide synthase (eNOS) to generate nitric oxide (NO), a key vasodilator. It is used in research to study vascular physiology and to experimentally model conditions like acute pancreatitis in both in vitro and in vivo settings.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1119-34-2
• MW: 210.66
• Purity: 99.51% (May vary between batches)
• Formula: C₆H₁₅ClN₄O₂
• SMILES: C(=O)([C@@H](N)CCCNC(=N)N)O.Cl
• Target: Amino Acids and Derivatives,NO Synthase,Endogenous Metabolite
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  Treatment with L-Arginine (0.3 mM) for 30 minutes significantly increases nitric oxide (NO) production in bovine aortic endothelial cells exposed to n-LDL and oxidized-LDL.
• In Vitro:
  In individuals with sickle cell anemia, oral administration of L-Arginine (0.1 g/kg) significantly reduces pulmonary arterial systolic pressure after 5 days. Continuous treatment with L-Arginine (4 mg/kg per minute for 1 hour) in rabbit limbs subjected to regional ischemia/reperfusion reduced superoxide production by cNOS, thereby increasing NO accumulation. In SV-129 mice, subcutaneous injection of L-Arginine (2 mg/kg) resulted in the upregulation of eNOS.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Arginine Hydrochloride, AminoAcidsandDerivatives, Amino Acids and Derivatives, (S)-(+)-Arginine hydrochloride, Endogenous Metabolite, EndogenousMetabolite, L-Arg, L-Arginine, L-arginine, L-Arginine HCl, L-Arginine HCl (L-Arg), LArginine hydrochloride, L-Arginine Hydrochloride, L-arginine Monohydrochloride, L-arginine monohydrochloride, NOSynthase, L Arginine hydrochloride, NOS, Inhibitor, inhibit, NO Synthase, Nitric oxide synthases

Compound Identifiers

PubChem CID

66250