L-NAME hydrochloride

SKU: orb1300649

Description

L-NAME hydrochloride

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 51298-62-5
• MW: 269.69
• Purity: 99.93%
• Formula: C₇H₁₅N₅O₄·HCl
• SMILES: Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
• Target: NOS,NO Synthase
• Solubility: H2O:27 mg/mL (100.11 mM);DMSO:250 mg/mL (926.99 mM)

Bioactivity

• Target IC50:
  eNOS:39 nM(Ki)|nNOS:15 nM(Ki)
• In Vivo:
  L-NAME (0.03-300 mg kg-1, i.v.) induces a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. L-NAME (100 mg kg-1, i.v.) inhibits significantl the hypotensive responses to ACh and bradykinin the increase in blood pressure and bradycardia produced by L-NAME is reversed by L-arginine (30-100 mg kg-1, i.v.) in a dose-dependent manner.
• Cell Research:
  rMC-1 cells are incubated in 5 or 25 mM glucose, with or without l-NAME (1 mM . Media is changed every Other day for up to 5 days. BREC cells are incubated in 5 or 25 mM glucose as well as inhibitor as described above for 5 days. Cell death is determined by light microscopy using a hemocytometer and a 0.4% trypan blue dye exclusion method the number of cells that do not exclud the dye is expressed per 1,000 total cells. A minimum of 800 cells is counted per assay (8 dishes, >100 cells counted per dish), an the assay is replicated three times on different days. (Only for Reference)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

NOS, L NAME hydrochloride, NOSynthase, L-NAME, L-NAME HCl, LNAME hydrochloride, L-NAME Hydrochloride, inhibit, Nitric oxide synthases, NG-Nitroarginine methyl ester, NG-Nitroarginine methyl ester Hydrochloride, NG-Nitroarginine methyl ester hydrochloride, NO Synthase, nNOS, N(G)-Nitro-L-arginine methyl ester, eNOS, iNOS, Inhibitor

Compound Identifiers

PubChem CID

135193