JR14a

SKU: orb1298193

Description

JR14a

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2411440-41-8
• MW: 533.47
• Purity: 99.76%
• Formula: C₂₅H₂₆Cl₂N₄O₃S
• SMILES: Cc1cc(sc1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
• Target: Complement System
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.19 mM);DMSO:250 mg/mL (468.63 mM)

Bioactivity

• In Vivo:
  JR14a reduces mast cell degranulation and macrophage infiltration in BR103-induced rat paw edema.
• In Vitro:
  In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages without inhibiting the agonist effects in the same concentration range as the related Complement protein C5a.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JR14a, JR-14a, inhibit, inflammation, Inhibitor, 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride, C3a, Complement System, ComplementSystem, complement

Compound Identifiers

PubChem CID

145996525