Recombinant MKI67 Antibody / Ki-67

SKU: orb2635991

Description

Proliferation marker protein Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.

Images & Validation

• Tested Applications: ELISA
• Dilution range: ELISA
• Reactivity: Human
• Application Notes:
  Optimal dilution of the recombinant MKI67 antibody should be determined by the researcher.

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Recombinant
• Isotype: Mouse IgG2b, kappa
• Clone No.: rMKI67/9616
• Immunogen: A recombinant fragment (within amino acids 2200-2500) of human MKI67 protein was used as the immunogen for the recombinant MKI67 antibody.
• Purification: Protein A/G affinity
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Disclaimer: For research use only

SDS-PAGE analysis of purified, BSA-free recombinant MKI67 antibody (clone rMKI67/9616) as confirmation of integrity and purity.

Quick Database Links

UniProt

P46013