ITD-1

SKU: orb1226991

Description

ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2; effectively clears the receptor from the cell surface and selectively inhibits intracellular signaling; selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells.

Key Properties

• CAS Number: 1099644-42-4
• MW: 415.524
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₉NO₃
• SMILES: O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC
• Target: TGFBR
• Solubility: DMSO: < 9 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ITD-1

Quick Database Links

Gene Symbol

TGFBR