Imipenem

SKU: orb1992144

Description

Imipenem is a broad-spectrum carbapenem antibiotic used to study resistant bacterial infections. Its applications include in vitro and in vivo research on carbapenem non-susceptible pathogens and Pseudomonas aeruginosa biofilm-associated diseases.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64221-86-9
• MW: 299.35
• Purity: 99.75% (May vary between batches)
• Formula: C₁₂H₁₇N₃O₄S
• SMILES: C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
• Target: Antifungal,Antibacterial,Antibiotic
• Solubility: DMSO:3 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  In a neutropenic mouse model of biofilm lung infection, the pharmacokinetic parameters of Imipenem (MK0787) were assessed following a single intraperitoneal (IP) administration at various doses (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg). The killing effect was observed to be time-dependent.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-Formimidoyl thienamycin, MK0787, Fungal

Compound Identifiers

PubChem CID

104838