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Cilastatin

SKU: orb1305299

Description

Cilastatin is a dehydropeptidase-I inhibitor co-administered with the antibiotic imipenem to prevent its renal degradation, thereby enhancing therapeutic efficacy. It also inhibits leukotriene D4 metabolism and is used in research involving bacterial infection models and studies of leukotriene-mediated inflammatory pathways.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number82009-34-5
MW358.45
Purity99.03% (May vary between batches)
FormulaC16H26N2O5S
SMILESCC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O
TargetAntibiotic|||Proteasome|||Antibacterial
SolubilityDMSO:45 mg/mL (125.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.58 mM)

Bioactivity

Target IC50
Metallob-lactamase enzyme CphA (bacterial):178 μM (IC50)|Renal dehydropeptidase I:0.1 μM (IC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, MK0791, MK-0791, MK 0791, metallob-lactamase, Cilastatin, CphA, dehydropeptidase, Dipeptidase 1, adjunct, Bacterial, Antibiotic, antibacterial, peptidase, zinc, Renal

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 70.00
10 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 100.00
50 mg
$ 130.00
100 mg
$ 170.00
200 mg
$ 240.00
500 mg
$ 390.00
DispatchUsually dispatched within 5-10 working days
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