Cilastatin

SKU: orb1305299

Description

Cilastatin is a dehydropeptidase-I inhibitor co-administered with the antibiotic imipenem to prevent its renal degradation, thereby enhancing therapeutic efficacy. It also inhibits leukotriene D4 metabolism and is used in research involving bacterial infection models and studies of leukotriene-mediated inflammatory pathways.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 82009-34-5
• MW: 358.45
• Purity: 97.76% (May vary between batches)
• Formula: C₁₆H₂₆N₂O₅S
• SMILES: CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O
• Target: Antibiotic,Antibacterial,Proteasome
• Solubility: DMSO:45 mg/mL (125.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.58 mM)

Bioactivity

• Target IC50:
  Metallob-lactamase enzyme CphA (bacterial):178 μM (IC50)|Renal dehydropeptidase I:0.1 μM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, MK0791, MK-0791, MK 0791, metallob-lactamase, Cilastatin, CphA, dehydropeptidase, Dipeptidase 1, adjunct, Bacterial, Antibiotic, antibacterial, peptidase, zinc, Renal

Compound Identifiers

PubChem CID

6435415