Imipenem monohydrate

SKU: orb1308410

Description

Imipenem monohydrate is a β-lactam carbapenem antibiotic derived from Streptomyces cattleya. It inhibits bacterial cell wall synthesis and exhibits broad-spectrum activity against Gram-positive and Gram-negative pathogens, making it valuable for in vitro susceptibility testing and research into bacterial resistance mechanisms.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 74431-23-5
• MW: 317.36
• Purity: 99.94%
• Formula: C₁₂H₁₉N₃O₅S
• SMILES: O.[H][C@]12CC(SCCNC=N)=C(N1C(=O)[C@@H]2[C@@H](C)O)C(O)=O
• Target: Antibacterial,Antibiotic
• Solubility: H2O:6.81 mg/mL (21.46 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  METHODS: To study the effect on tuberculosis, Imipenem monohydrate (100 mg/kg) was administered subcutaneously to a mouse model of tuberculosis twice daily for 28 days. RESULTS: Imipenem significantly reduced the number of Mycobacterium tuberculosis in the lungs and spleens, and increased the survival rate of the mice. METHODS: To assess the effect on the kinetics of the inflammatory response in a mouse model of sepsis, Imipenem monohydrate (25-125 mg/kg) was administered subcutaneously to CLP-induced septic mice once daily for three days. RESULTS: Subcutaneous injection of Imipenem had a dose-dependent effect on the inflammatory response in septic mice. In septic mice, the 25 mg/kg dose of Imipenem resulted in better pathology, lower inflammatory mediators and improved survival.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, infection, ntibiotic, N-Formimidoyl thienamycin, N-Formimidoyl thienamycin monohydrate, P. aeruginosa, MK0787, MK-0787, MK 0787, PBPs, thienamycin, β-Lactamase

Compound Identifiers

PubChem CID

5282372