IDO-IN-7

SKU: orb1307405

Description

IDO-IN-7 is a potent small molecule inhibitor of indoleamine 2,3-dioxygenase (IDO1), an analogue of NLG-919. It is used in research to investigate the IDO pathway in immunology and oncology, with applications in both in vitro cellular assays and in vivo tumor model studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1402836-58-1
• MW: 282.38
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₂N₂O
• SMILES: OC(CC1c2ccccc2-c2cncn12)C1CCCCC1
• Target: Indoleamine 2,3-Dioxygenase (IDO),IDO
• Solubility: DMSO:48 mg/mL (169.98 mM);Ethanol:26 mg/mL (92.07 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.08 mM)

Bioactivity

• Target IC50:
  IDO:75 nM(EC50)
• In Vivo:
  NLG919 effectively blocks the IDO-induced suppression of T-cell responses, restoring T-cell activity (ED50=80 nM). In mouse dendritic cells (DCs) expressing IDO from tumor lymph nodes (ED50=120 nM), NLG919 abolishes the IDO-induced inhibition of antigen-specific T-cells (OT-1).
• In Vitro:
  In mice bearing B16F10 tumors, NLG919 significantly enhanced the antitumor response of pmel-1 resting cells to homologous hgp100 peptide and CpG-1826.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Indoleamine2,3Dioxygenase(IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, Indoleamine 2,3-Dioxygenase, Indoleamine 2,3Dioxygenase (IDO), Navoximod, Navoximod analogue, NLG 919, NLG919, NLG-919, NLG919 analogue, NLG-919 analogue, IDO, IDO IN 7, IDOIN7, IDO-IN-7, GDC 0919, GDC0919, GDC-0919, GDC-0919, GDC-0919 analogue

Compound Identifiers

PubChem CID

66558287