NLG919

SKU: orb1226356

Description

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.(In Vitro):IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.

Key Properties

• CAS Number: 1402836-58-1
• MW: 282.38
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂N₂O
• SMILES: OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4
• Target: IDO
• Solubility: Ethanol: 56 mg/mL warmed (198.31 mM); DMSO: 15 mg/mL warmed (53.11 mM)

Bioactivity

• In Vitro:
  IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50 = 38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GDC-0919

Quick Database Links

Gene Symbol

IDO