ICILIN

SKU: orb1225179

Description

Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.

Key Properties

• CAS Number: 36945-98-9
• MW: 311.29
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₃N₃O₄
• SMILES: O=C1NC(C2=CC=CC([N+]([O-])=O)=C2)=CCN1C3=CC=CC=C3O
• Target: TRP/TRPV Channel
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin (3 mg/kg; s. c.) induces“Wet dog shake” in mice. Animal model: The C57BL/6 mice 9–10 weeks (adult, 26-30 g) or 24 months (aged, 35-42g). Dosage: 3 mg/kg. Administration: Injected s. c. Result: Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”), which were TRPM8-dependent.
• In Vitro:
  Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+ dependence. Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization. Cell Viability Assay Cell line: TRPM8-expressing oocytes or HEK293 cells. Concentration: 10 μM. Incubation time: 3 minutes for TRPM8-expressing oocytes; 1 minute for HEK293 cells. Result: Activated membrane currents with variable delay of onset in voltage-clamped TRPM8-expressing oocytes or HEK293 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG 3-5

Quick Database Links

Gene Symbol

TRP/TRPV Channel