TC-I2000

SKU: orb1298925

Description

TC-I2000 is a potent and selective TRPM8 channel antagonist, inhibiting icilin-induced activation with an IC50 of 53 nM in recombinant systems. This small molecule inhibitor is a valuable research tool for studying TRPM8's role in thermosensation, pain, and cancer in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1159996-20-9
• MW: 414.4
• Purity: 98.87% (May vary between batches)
• Formula: C₂₃H₁₈F₄N₂O
• SMILES: C(NC1=CC=C(F)C=C1)(=O)N2C(C=3C(CC2)=CC=CC3)C4=CC=C(C(F)(F)F)C=C4
• Target: TRP/TRPV Channel
• Solubility: DMSO:4.15 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  TRPM8:<5 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TC I2000, TC-I 2000, TCI2000, TC-I2000, TC-I-2000, TRP Channel, TRPM8, TRPV Channel, TRPChannel, TRPVChannel

Compound Identifiers

PubChem CID

57326210