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Catalog Number | orb749581 |
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Category | Antibodies |
Description | Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM1 also binds to CD43 and to Plasmodium falciparum infected RBCs and may also be related to progression and metastasis of tumors. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | F4-31C2 |
Tested applications | FACS, Functional Studies, IF |
Reactivity | Human |
Isotype | Mouse IgG2a, kappa |
Immunogen | Human umbilical cord vein endothelial cells (HUVEC) were used as the immunogen for the ICAM1 antibody. |
Dilution range | Functional studies (order BSA/sodium azide-free format),Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 0.5-1ug/ml |
Purity | Protein G affinity chromatography |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
Hazard Information | This ICAM1 antibody is available for research use only. |
UniProt ID | P05362 |
Storage | Store the ICAM1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide). |
Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide |
Note | For research use only |
Application notes | Optimal dilution of the ICAM1 antibody should be determined by the researcher. |
Expiration Date | 12 months from date of receipt. |
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