(±)-Huperzine A

SKU: orb1308899

Description

(±)-Huperzine A is a racemic Lycopodium alkaloid that acts as a selective, reversible acetylcholinesterase (AChE) inhibitor. It is widely used in Alzheimer's disease research, with applications in both in vitro enzyme assays and in vivo cognitive function studies in animal models.

Research Area

Neuroscience

Key Properties

• CAS Number: 120786-18-7
• MW: 242.32
• Purity: 99.84% (May vary between batches)
• Formula: C₁₅H₁₈N₂O
• SMILES: C\C=C1/C2Cc3[nH]c(=O)ccc3C1(N)CC(C)=C2
• Target: Cholinesterase (ChE)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.25 mM);DMSO:50 mg/mL (206.34 mM)

Bioactivity

• In Vitro:
  (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflammation-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Huperzine A, Inhibitor, inhibit, AChE, (±)-Huperzine A, (±)Huperzine A, (±) Huperzine A, Cholinesterase (ChE)

Compound Identifiers

PubChem CID

5912039