(-)-Huperzine A

SKU: orb1227130

Description

A naturally occurring sesquiterpene alkaloid that a reversible and selective inhibitor of acetylcholinesterase (AChE); has been used for improving memory, cognitive and behavioral function in Alzheimer's disease; activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.Alzheimer's Disease Approved(In Vitro):(-)-Huperzine A (1 μM; 2 hours) attenuates Aβ23-35 (20 μM)-induced neuronal injury.(-)-Huperzine A (100 μM) reversibly inhibits the NMDA-induced current (IC50=126 μM) in whole-cell voltage-clamp recording in CA1 pyramidal neurons acutely dissociated from rat hippocampus.(In Vivo):(-)-Huperzine A (0.1-0.2 mg/kg; i.p.; daily; for 12 days) can alleviate the cognitive dysfunction and neuronal degeneration induced by i.c.v. infusion of beta-amyloid protein-(1-40) in rats.

Key Properties

• CAS Number: 102518-79-6
• MW: 242.3162
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₈N₂O
• SMILES: O=C(N1)C=CC2=C1C[C@H]3/C([C@@]2(N)CC(C)=C3)=C\C
• Target: AChE
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats (220-280 g). Dosage: 0.1 mg/kg, 0.2 mg/kg. Administration: Intraperitoneal injection, daily, for 12 days. Result: Partly reversed the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax and P53 proteins and reduced the apoptosis that normally followed b-amyloid injection; alleviated the cognitive dysfunction induced by b-amyloid protein-(1-40).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Huperzine A

Quick Database Links

Gene Symbol

AChE