HIV-1 integrase inhibitor 8

SKU: orb1689287

Description

HIV-1 integrase inhibitor 8 is a small molecule research compound that selectively targets the viral integrase enzyme, a key component in the HIV-1 replication cycle. It is utilized in both in vitro enzymatic assays and cell-based studies to investigate integration mechanisms and evaluate potential antiviral strategies.

Research Area

Infectious Disease & Virology, Infectious Disease & Virology; Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1568-80-5
• MW: 308.41
• Purity: 98.91% (May vary between batches)
• Formula: C₂₁H₂₄O₂
• SMILES: CC1(C)CC2(CC(C)(C)c3ccc(O)cc23)c2cc(O)ccc12
• Target: HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.48 mM);DMSO:45 mg/mL (145.91 mM)

Bioactivity

• In Vitro:
  HIV-1 integrase inhibitor 8 were tested against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay, IC50=275μM and 231μM, respectively. HIV-1 integrase inhibitor 8 were retested using Mg2+ and the IC50 of against strand-transfer (ST) activities was 200μM. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 of 500 µM and 200 µM, respectively. HIV-1 integrase inhibitor 8 induces cell cytotoxicity with LD50 of 20 μM in HeLa cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIV-1 integrase, HIV Protease, HIVProtease

Compound Identifiers

PubChem CID

74071