Bictegravir Sodium

SKU: orb1694663

Description

Bictegravir Sodium is a potent and selective HIV-1 integrase strand transfer inhibitor (INSTI) with an IC50 of 7.5 nM. It demonstrates robust antiviral activity in vitro and has been evaluated in clinical studies for HIV-1 treatment, showing low cytotoxicity in cellular assays.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 1807988-02-8
• MW: 471.36
• Purity: 99.97%
• Formula: C₂₁H₁₇F₃N₃NaO₅
• SMILES: O=C(C([O-])=C1C2=O)C(C(NCC3=C(F)C=C(F)C=C3F)=O)=CN1C[C@@H](O4)N2[C@@H]5C[C@H]4CC5.[Na+]
• Target: HIV Protease
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HIV-1 integrase:7.5 nM
• In Vitro:
  Bictegravir Sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ∼6,800 in MT-2 cells and ∼1,500 in MT-4 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bictegravir Sodium, GS-9883 Sodium, HIV Integrase, HIV Protease, HIVProtease

Compound Identifiers

PubChem CID

102593990