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H122

SKU: orb2945157

Description

H122 is a potent TEAD-targeting PROTAC degrader with low nanomolar activity against TEAD1-4. It downregulates Myc expression, inhibits mesothelioma cell growth in vitro, and demonstrates antitumor efficacy in mouse models, supporting research in Hippo pathway and cancer therapeutics.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW838.319
FormulaC45H45ClFN5O8
SMILESCOCCOC1=C(C(=C(C=C1)C(=O)N)C2=C(C=CC3=C2C[C@@](O3)(CNCCC4CCN(CC4)C5=CC6=C(C=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)C8=CC=CC=C8)Cl)F
TargetPROTACs,YAP,c-Myc

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information