Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

GSK3β inhibitor II

SKU: orb1704915

Description

GSK3β inhibitor II is a selective small molecule inhibitor of glycogen synthase kinase-3 beta. It is widely used in vitro and in vivo to investigate pathways in Alzheimer's disease research, including tau phosphorylation and neuroprotection.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number478482-75-6
MW395.22
Purity99.48% (May vary between batches)
FormulaC14H10IN3OS
SMILESIc1cccc(CSc2nnc(o2)-c2ccncc2)c1
TargetGSK-3
SolubilityDMSO:5.5 mg/mL (13.92 mM)

Bioactivity

In Vitro
GSK3 β Inhibitor II exhibits hydrophobic interactions with Ile62, Phe67, Val70, Ala83, and Leu188, ionic interactions with Lys85, and hydrogen bonding interactions with Lys85 and Val135 residues. GSK3 β Inhibitor II forms a hydrogen bond with Val135 .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK3β inhibitor II, GSK-3β, GSK3beta inhibitor II, GSK3b inhibitor II, GSK 3 Inhibitor II, GSK3, GSK3 Inhibitor II

Similar Products

  • Cu(II)GTSM [orb1690346]

    99.21% (May vary between batches)

    68341-14-0

    293.86

    C6H10CuN6S2

    100 mg, 1 ml x 10 mM (in DMSO), 25 mg, 5 mg, 1 mg, 50 mg, 10 mg
  • Wedelolactone [orb1224805]

    >98% (HPLC)

    524-12-9

    314.3

    C16H10O7

    5 mg, 50 mg, 100 mg, 500 mg, 1 g, 10 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 90.00
25 mg
$ 140.00
50 mg
$ 210.00
100 mg
$ 270.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry