Cu(II)GTSM

SKU: orb1690346

Description

Cu(II)GTSM is a cell-permeable copper complex that acts as a potent GSK3β inhibitor. It reduces amyloid-β trimers and phosphorylated tau, and has been shown to rescue cognitive function in Alzheimer's disease mouse models, supporting its use in both in vitro and in vivo neurodegenerative disease research.

Research Area

Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 68341-14-0
• MW: 293.86
• Purity: 99.21%
• Formula: C₆H₁₀CuN₆S₂
• SMILES: N1=C([S-][Cu+2]23[S-]C(=N[N]3=CC=[N]12)NC)NC
• Target: GSK-3,Beta Amyloid

Bioactivity

• In Vivo:
  Treatment of AD mice with Cu(II)GTSM (10 mg/kg) can reduce the level of brain Aβ trimers in AD mice, restore the cognitive ability of AD mice to the expected level of healthy, cognitively normal mice, and reverse the cognitive deficits of APP/PS1 transgenic AD mice.
• In Vitro:
  Methods: PC12 cells treated with NGF for 48 hours were treated with Cu(II)GTSM (25, 50, 100 nM, 18 hours) and then examined. Results: MTT assay Results showed a small but significant loss of MTT reduction at 25 and 50 nMd of Cu(II)GTSM treatment; LDH assay showed that there was actually a small but significant reduction in LDH release when using 100 nM Cu(II)GTSM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cu(II)GTSM, Cu-GTSM

Quick Database Links

Gene Symbol

GSK-3,Beta Amyloid