GSK-3β inhibitor 8

SKU: orb1694515

Description

GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent, selective thienopyrimidine-based compound with an IC50 of 64 nM. It acts as a negative regulator of Wnt signaling and has been shown to stimulate β-cell proliferation in research models, supporting its use in diabetes and regenerative biology studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1139875-74-3
• MW: 413.92
• Purity: 98.46% (May vary between batches)
• Formula: C₂₀H₂₀ClN₅OS
• SMILES: C(=O)(C1=C(Cl)C=C(NC=2N=C(C=CN2)C3=CC=CS3)C=C1)N4CCN(C)CC4
• Target: GSK-3,Wnt/beta-catenin
• Solubility: DMSO:Soluble

Bioactivity

• Target IC50:
  GSK-3β:64 nM
• In Vitro:
  GSK-3β inhibitor 8 (Compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. GSK-3β inhibitor 8 (2 μM; 72 h) increases replicating R7T1 β cells approximately 2-fold. GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces activation of the Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM. GSK-3β inhibitor 8 (2 μM; 72 h) stimulates β-catenin translocation into the nucleus in HEK293 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, GSK-3b inhibitor 8, GSK-3beta inhibitor 8, GSK3beta Inhibitor XVIII, GSK3b Inhibitor XVIII, GSK-3β, GSK-3β inhibitor 8, GSK3β Inhibitor XVIII, GSK3, betacatenin, beta-catenin, bcatenin

Compound Identifiers

PubChem CID

46215122