TDZD-8

SKU: orb1300998

Description

TDZD-8

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 327036-89-5
• MW: 222.26
• Purity: 99.61%
• Formula: C₁₀H₁₀N₂O₂S
• SMILES: Cn1sc(=O)n(Cc2ccccc2)c1=O
• Target: GSK-3
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9 mM);DMSO:70 mg/mL (314.95 mM);Ethanol:44.5 mg/mL (200.22 mM)

Bioactivity

• Target IC50:
  GSK-3β:2 μM
• In Vitro:
  TDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK3, GSK-3, GSK-3b Inhibitor I, GSK-3beta Inhibitor I, GSK-3β, GSK-3β Inhibitor I, Inhibitor, NP 01139, NP01139, NP-01139, inhibit, TDZD-8, TDZD 8, TDZD8

Compound Identifiers

PubChem CID

4124851