Gossypol

SKU: orb1300699

Description

Gossypol (BL 193) Acetate is a cell-permeable polyphenol that inhibits multiple dehydrogenase enzymes. It is widely used in biochemical and cancer research, with studies in both in vitro and in vivo models investigating its potential biological activities.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 303-45-7
• MW: 518.55
• Purity: 98.00% (May vary between batches)
• Formula: C₃₀H₃₀O₈
• SMILES: CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O
• Target: Bcl-2 Family,Dehydrogenase
• Solubility: DMSO:250 mg/mL (482.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.64 mM)

Bioactivity

• Target IC50:
  BCL-XL:0.5-0.6 μM (Ki)|Bcl-2:0.2-0.3 mM (Ki)
• In Vitro:
  Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro.
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• Cell Research:
  MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gossypol, Pogosin, inhibit, Inhibitor, NSC56817, NSC-56817, NSC 56817, Bcl-2 Family, BL 193, BL193, BL-193, dehydrogenase

Compound Identifiers

PubChem CID

3503