(S)-Gossypol acetic acid

SKU: orb1707767

Description

(S)-(+)-Gossypol acetic acid is a BH3 mimetic that binds and inhibits anti-apoptotic proteins Bcl-2 and Bcl-xL. This activity promotes apoptosis and inhibits cell proliferation, making it a tool for studying cell death mechanisms in cancer research, both in vitro and in vivo.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1189561-66-7
• MW: 578.61
• Purity: 98.69% (May vary between batches)
• Formula: C₃₂H₃₄O₁₀
• SMILES: O=CC1=C(O)C(O)=C(C2=CC(=C(C(O)=C12)C3=C(O)C4=C(C=O)C(O)=C(O)C(=C4C=C3C)C(C)C)C)C(C)C.O=C(O)C
• Target: Bcl-2 Family
• Solubility: H2O:< 1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.46 mM);DMSO:40 mg/mL (69.13 mM)

Bioactivity

• In Vivo:
  In BALB/c nude mice bearing CNE-2 xenograft tumors, intraperitoneal administration of (S)-Gossypol acetic acid at 20 mg/kg/day for 21 days significantly inhibited tumor growth (~60% reduction in volume) without notable weight loss or systemic toxicity.
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• In Vitro:
  (S)-Gossypol acetic acid inhibits proliferation and induces apoptosis in human nasopharyngeal carcinoma CNE-2 cells in a dose-dependent manner (2.5-20 μM, 24 h). (S)-Gossypol acetic acid decreases mitochondrial membrane potential, upregulates Bax, downregulates Bcl-2, and activates caspase-3.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gossypol, Gossypol acetic acid, (S)-(+)-Gossypol acetic acid, (S)Gossypol (acetic acid), (S)-Gossypol acetic acid, (S) Gossypol (acetic acid), acetic acid, Bcl-2

Compound Identifiers

PubChem CID

227456