Gossypolone

SKU: orb1697064

Description

Gossypolone, a key gossypol metabolite, is a bioactive small molecule that inhibits Notch and Wnt signaling pathways. It induces apoptosis and is utilized in cancer research, particularly for studying cell proliferation and death in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 4547-72-2
• MW: 546.52
• Purity: 96.66% (May vary between batches)
• Formula: C₃₀H₂₆O₁₀
• SMILES: C(=O)C1=C2C(=C(C(C)C)C(O)=C1O)C(=O)C(C)=C(C2=O)C=3C(=O)C=4C(C(=O)C3C)=C(C(C)C)C(O)=C(O)C4C=O
• Target: Others,Gamma-secretase,Wnt/beta-catenin,DNA/RNA Synthesis
• Solubility: DMSO:5.47 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  Gossypolone-PEGylated liposome via tail vein injection inhibits the growth of human colon cancer DLD-1 xenografts in nude mice.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, Gammasecretase, Gossypolone, Notch, Wnt/β-catenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, βcatenin

Compound Identifiers

PubChem CID

197045